The original ride height had the car sitting about one inch lower in the rear than the front. To get a level look order the rear springs 1-inch higher than stock.

In keeping with GM practice, the GTO received a major body redesign for 1966, but the split grille Pontiac design theme remained similar. The pinched-waist, "coke bottle" and "flying buttress" c-pillar were the most visual elements of the restyle. The rear tail light panel also saw a big change, with distinctive louvered tail lights as the major design element. As with the 2+2, the GTO was now made a separate model rather than a performance option on a lower series.

The same procedural policy that allowed for the body redesign mandated no major drive train changes for this year, so engine choices remained unchanged, although a new "XS" option, which featured revised cam timing and fresh air intake through the existing hood scoop, became available. The number of RAM AIR-equipped GTOs sold was only about 185.

1966 was the best sales year for the GTO, with 96,946 units sold.